SOCS1 function in BCR-ABL mediated myeloproliferative disease is dependent on the cytokine environment.
Treatment with tyrosine kinase inhibitors is the standard of care for Philadelphia chromosome positive leukemias.However the eradication of leukemia initiating cells remains a challenge.Circumstantial evidence suggests that the cytokine microenvironment may Lighting LED play a role in BCR-ABL mediated leukemogenesis and in imatinib resistance.Gene